*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 22.00 | Week 08, 2019 | SF | CarCar | 4 Tackles, 3.0 Sacks, 1 Int, 1 PD |
| 2. | 18.00 | Week 16, 2022 | SF | WasWas | 5 Tackles, 2 Assists, 2.0 Sacks, 1 FF |
| 2. | 18.00 | Week 13, 2022 | SF | MiaMia | 3 Tackles, 3.0 Sacks, 1 FF |
| 2. | 18.00 | Week 05, 2019 | SF | CleCle | 4 Tackles, 2.0 Sacks, 1 FF, 1 Fum Rcvy |
| 5. | 16.00 | Week 17, 2024 | SF | DetDet | 5 Tack, 3 Ass, 2.00 Sack |
| 5. | 16.00 | Week 10, 2023 | SF | @Jac@Jac | 2 Tackles, 1 Assist, 1.5 Sacks, 1 FF, 1 Fum Rcvy, 1 PD |
| 7. | 15.00 | Week 04, 2024 | SF | NE NE | 4 Tack, 1 Ass, 1.00 Sack, 1 FF, 1 Fum Rcvy |
| 8. | 14.00 | Week 02, 2021 | SF | @PHI@PHI | 2 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 9. | 13.00 | Week 02, 2024 | SF | @Min@Min | 4 Tack, 1 Ass, 2.00 Sack |
| 9. | 13.00 | Week 14, 2023 | SF | SeaSea | 4 Tackles, 2 Assists, 1.5 Sacks, 1 PD |
| 9. | 13.00 | Week 12, 2023 | SF | @Sea@Sea | 3 Tackles, 2 Assists, 2.0 Sacks |
| 12. | 12.00 | Week 02, 2022 | SF | SeaSea | 4 Tackles, 2.0 Sacks |
| 13. | 11.00 | Week 04, 2022 | SF | LARLAR | 3 Tackles, 2.0 Sacks |
| 13. | 11.00 | Week 14, 2021 | SF | @CIN@CIN | 2 Tackles, 1 Assist, 2.0 Sacks |
| 13. | 11.00 | Week 11, 2021 | SF | @Jac@Jac | 3 Tackles, 2.0 Sacks |
| 13. | 11.00 | Week 08, 2021 | SF | @CHI@CHI | 3 Tackles, 2.0 Sacks |
| 13. | 11.00 | Week 07, 2019 | SF | @Was@Was | 5 Tackles, 2 Assists, 1.0 Sack |
| 18. | 10.00 | Week 11, 2024 | SF | SeaSea | 2 Tack, 2 Ass, 1.50 Sack |
| 18. | 10.00 | Week 05, 2024 | SF | AriAri | 4 Tack, 1 Int, 1 PD |
| 18. | 10.00 | Week 13, 2021 | SF | @SEA@SEA | 3 Tackles, 1.0 Sack, 1 FF |
| 18. | 10.00 | Week 12, 2019 | SF | GBGB | 2 Tackles, 1 Assist, 1.0 Sack, 1 Fum Rcvy |
| 22. | 9.00 | Week 01, 2022 | SF | @CHI@CHI | 4 Tackles, 1 Assist, 1.0 Sack |
| 22. | 9.00 | Week 05, 2021 | SF | @ARI@ARI | 4 Tackles, 1 Assist, 1.0 Sack |
| 22. | 9.00 | Week 01, 2020 | SF | AriAri | 3 Tackles, 3 Assists, 1 FF |
| 25. | 8.00 | Week 10, 2024 | SF | @TB @TB | 3 Tack, 1 Ass, 1.00 Sack |
| 25. | 8.00 | Week 15, 2023 | SF | @Ari@Ari | 1 Tackle, 1.0 Sack, 1 FF |
| 25. | 8.00 | Week 06, 2023 | SF | @Cle@Cle | 3 Tackles, 1.0 Sack, 1 PD |
| 25. | 8.00 | Week 10, 2022 | SF | LACLAC | 4 Tackles, 1.0 Sack |
| 25. | 8.00 | Week 07, 2022 | SF | KCKC | 4 Tackles, 1.0 Sack |
| 25. | 8.00 | Week 15, 2021 | SF | ATLATL | 1 Tackle, 1.0 Sack, 1 FF |
| 25. | 8.00 | Week 01, 2021 | SF | @DET@DET | 4 Tackles, 1.0 Sack |
| 25. | 8.00 | Week 15, 2019 | SF | AtlAtl | 1 Tackle, 2 Assists, 1.0 Sack, 1 PD |
| 25. | 8.00 | Week 10, 2019 | SF | SeaSea | 3 Tackles, 5 Assists |
| 34. | 7.00 | Week 08, 2024 | SF | DalDal | 2 Tack, 1 Ass, 1.00 Sack |
| 34. | 7.00 | Week 11, 2023 | SF | TBTB | 3 Assists, 1.0 Sack |
| 34. | 7.00 | Week 03, 2023 | SF | NYGNYG | 2 Tackles, 1 Assist, 1.0 Sack |
| 34. | 7.00 | Week 15, 2022 | SF | @Sea@Sea | 1 Tackle, 1 Assist, 1.0 Sack, 1 PD |
| 34. | 7.00 | Week 12, 2022 | SF | NONO | 2 Tackles, 1 Assist, 1.0 Sack |
| 34. | 7.00 | Week 11, 2022 | SF | @Ari@Ari | 3 Tackles, 1.0 Sack |
| 34. | 7.00 | Week 08, 2022 | SF | @LAR@LAR | 2 Tackles, 1 Assist, 1.0 Sack |
| 34. | 7.00 | Week 18, 2021 | SF | @LAR@LAR | 2 Tackles, 3 Assists, 0.5 Sack |
| 34. | 7.00 | Week 09, 2021 | SF | ARIARI | 3 Tackles, 1 Assist, 1 FF |
| 34. | 7.00 | Week 04, 2021 | SF | SEASEA | 1 Tackle, 2 Assists, 1.0 Sack |
| 34. | 7.00 | Week 01, 2019 | SF | @TB@TB | 2 Tackles, 1 Assist, 1.0 Sack |
| 45. | 6.00 | Week 13, 2023 | SF | @Phi@Phi | 2 Tackles, 4 Assists |
| 45. | 6.00 | Week 05, 2023 | SF | DalDal | 2 Tackles, 2 Assists, 0.5 Sack |
| 45. | 6.00 | Week 18, 2022 | SF | AriAri | 2 Tackles, 1.0 Sack |
| 45. | 6.00 | Week 03, 2022 | SF | @Den@Den | 1 Tackle, 1 Assist, 1.0 Sack |
| 45. | 6.00 | Week 12, 2021 | SF | MINMIN | 2 Tackles, 1.0 Sack |
| 45. | 6.00 | Week 10, 2021 | SF | LARLAR | 1 Tackle, 1.0 Sack, 1 PD |