*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 18.00 | Week 12, 2022 | Buf | @Det@Det | 4 Tackles, 2 Assists, 1.0 Sack, 1 FF, 1 Fum Rcvy, 1 Safety |
| 2. | 16.00 | Week 13, 2019 | Buf | @Dal@Dal | 3 Tackles, 1 Assist, 2.0 Sacks, 1 FF, 1 PD |
| 3. | 13.00 | Week 05, 2023 | Buf | JacJac | 5 Tackles, 4 Assists, 1.0 Sack |
| 4. | 12.00 | Week 17, 2023 | Buf | NENE | 2 Tackles, 1.0 Sack, 1 Int, 1 PD |
| 4. | 12.00 | Week 16, 2023 | Buf | @LAC@LAC | |
| 6. | 11.00 | Week 17, 2024 | Buf | NYJNYJ | 3 Tack, 1 Ass, 1.00 Sack, 1 FF |
| 6. | 11.00 | Week 15, 2024 | Buf | @Det@Det | 3 Tack, 1 Ass, 1.00 Sack, 1 FF |
| 8. | 10.00 | Week 03, 2023 | Buf | @Was@Was | 2 Tackles, 2 Assists, 1.5 Sacks |
| 8. | 10.00 | Week 16, 2022 | Buf | @Chi@Chi | 4 Tackles, 1.0 Sack, 2 PD |
| 8. | 10.00 | Week 18, 2021 | Buf | NYJNYJ | 2 Tackles, 2 Assists, 1.5 Sacks |
| 8. | 10.00 | Week 12, 2020 | Buf | LACLAC | 1 Tackle, 2 Assists, 1.0 Sack, 1 FF |
| 12. | 9.00 | Week 02, 2020 | Buf | @Mia@Mia | 4 Tackles, 1.0 Sack, 1 PD |
| 13. | 8.00 | Week 17, 2021 | Buf | ATLATL | 2 Tackles, 2 Assists, 1.0 Sack |
| 13. | 8.00 | Week 16, 2021 | Buf | @NE@NE | 3 Tackles, 1 Assist, 1.0 Sack |
| 13. | 8.00 | Week 15, 2020 | Buf | @DEN@DEN | 2 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 16. | 7.00 | Week 02, 2024 | Buf | @Mia@Mia | 3 Tack, 1.00 Sack |
| 16. | 7.00 | Week 11, 2023 | Buf | NYJNYJ | 3 Tackles, 1.0 Sack |
| 16. | 7.00 | Week 04, 2023 | Buf | MiaMia | 3 Tackles, 1.0 Sack |
| 16. | 7.00 | Week 01, 2023 | Buf | @NYJ@NYJ | 3 Tackles, 2 Assists, 0.5 Sack |
| 16. | 7.00 | Week 12, 2021 | Buf | @NO@NO | 3 Tackles, 1 Assist, 0.5 Sack, 1 PD |
| 16. | 7.00 | Week 11, 2019 | Buf | @Mia@Mia | 2 Tackles, 1 Assist, 1.0 Sack |
| 22. | 6.00 | Week 14, 2023 | Buf | @KC@KC | 1 Tackle, 2 Assists, 0.5 Sack, 1 PD |
| 22. | 6.00 | Week 08, 2023 | Buf | TBTB | 1 Tackle, 1 Assist, 1.0 Sack |
| 22. | 6.00 | Week 10, 2020 | Buf | @ARI@ARI | 3 Tackles, 2 Assists, 1 PD |
| 22. | 6.00 | Week 07, 2019 | Buf | MiaMia | 1 Tackle, 1 Assist, 1.0 Sack |
| 22. | 6.00 | Week 05, 2019 | Buf | @Ten@Ten | 3 Tackles, 3 Assists |
| 27. | 5.00 | Week 07, 2024 | Buf | TenTen | 1 Tack, 1 Ass, 1 FF |
| 27. | 5.00 | Week 12, 2023 | Buf | @Phi@Phi | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 11, 2022 | Buf | CleCle | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 15, 2021 | Buf | CARCAR | 2 Tackles, 1 FF |
| 27. | 5.00 | Week 14, 2019 | Buf | BalBal | 3 Tackles, 2 Assists |
| 27. | 5.00 | Week 12, 2019 | Buf | DenDen | 1 Tackle, 1.0 Sack |
| 27. | 5.00 | Week 08, 2019 | Buf | PhiPhi | 3 Tackles, 2 Assists |
| 34. | 4.00 | Week 08, 2024 | Buf | @Sea@Sea | 1 Tack, 3 Ass |
| 34. | 4.00 | Week 10, 2023 | Buf | DenDen | 3 Tackles, 1 Assist |
| 34. | 4.00 | Week 14, 2022 | Buf | NYJNYJ | 1 Tackle, 3 Assists |
| 34. | 4.00 | Week 10, 2022 | Buf | MinMin | 1 Tackle, 1 Assist, 0.5 Sack |
| 34. | 4.00 | Week 09, 2022 | Buf | @NYJ@NYJ | 2 Tackles, 2 Assists |
| 34. | 4.00 | Week 04, 2021 | Buf | HOUHOU | 3 Tackles, 1 Assist |
| 34. | 4.00 | Week 17, 2019 | Buf | NYJNYJ | 3 Tackles, 1 Assist |
| 34. | 4.00 | Week 16, 2019 | Buf | @NE@NE | 2 Tackles, 2 Assists |
| 42. | 3.00 | Week 14, 2024 | Buf | @LAR@LAR | 3 Ass |
| 42. | 3.00 | Week 03, 2024 | Buf | JacJac | 2 Tack, 1 Ass |
| 42. | 3.00 | Week 02, 2023 | Buf | LVLV | 2 Tackles, 1 Assist |
| 42. | 3.00 | Week 13, 2021 | Buf | NENE | 3 Tackles |
| 42. | 3.00 | Week 11, 2021 | Buf | INDIND | 1 Tackle, 1 Assist, 1 PD |
| 42. | 3.00 | Week 01, 2021 | Buf | PITPIT | 3 Tackles |
| 42. | 3.00 | Week 06, 2020 | Buf | KCKC | 3 Tackles |
| 42. | 3.00 | Week 04, 2020 | Buf | @LV@LV | 3 Tackles |
| 42. | 3.00 | Week 02, 2019 | Buf | @NYG@NYG |