*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 21.00 | Week 14, 2022 | SF | TBTB | 10 Tackles, 5 Assists, 1 Int, 1 PD |
| 2. | 18.00 | Week 13, 2022 | SF | MiaMia | 7 Tackles, 1 Assist, 1 TD, 1 Fum Rcvy, 1 PD |
| 2. | 18.00 | Week 01, 2021 | SF | @DET@DET | 4 Tackles, 2 Assists, 1 Int, 1 TD, 1 PD |
| 4. | 15.00 | Week 04, 2022 | SF | LARLAR | 12 Tackles, 3 Assists |
| 5. | 14.00 | Week 10, 2019 | SF | SeaSea | 3 Tackles, 5 Assists, 1 Int, 1 PD |
| 6. | 13.00 | Week 02, 2023 | SF | @LAR@LAR | 7 Tackles, 5 Assists, 1 PD |
| 6. | 13.00 | Week 15, 2022 | SF | @Sea@Sea | 4 Tackles, 4 Assists, 1 FF, 2 PD |
| 6. | 13.00 | Week 11, 2022 | SF | @Ari@Ari | 8 Tackles, 1 Assist, 1 FF, 1 PD |
| 6. | 13.00 | Week 17, 2019 | SF | @Sea@Sea | 11 Tackles, 2 Assists |
| 6. | 13.00 | Week 16, 2019 | SF | LARLAR | 9 Tackles, 4 Assists |
| 11. | 12.00 | Week 16, 2023 | SF | BalBal | |
| 11. | 12.00 | Week 11, 2023 | SF | TBTB | 4 Tackles, 4 Assists, 0.5 Sack, 2 PD |
| 11. | 12.00 | Week 18, 2021 | SF | @LAR@LAR | 5 Tackles, 7 Assists |
| 14. | 11.00 | Week 05, 2022 | SF | @Car@Car | 4 Tackles, 7 Assists |
| 14. | 11.00 | Week 10, 2020 | SF | @NO@NO | 7 Tackles, 4 Assists |
| 16. | 10.00 | Week 17, 2023 | SF | @Was@Was | 6 Tackles, 4 Assists |
| 16. | 10.00 | Week 07, 2023 | SF | @Min@Min | 8 Tackles, 2 Assists |
| 16. | 10.00 | Week 05, 2023 | SF | DalDal | 5 Tackles, 1.0 Sack, 1 PD |
| 16. | 10.00 | Week 04, 2023 | SF | AriAri | 8 Tackles, 2 Assists |
| 16. | 10.00 | Week 03, 2022 | SF | @Den@Den | 5 Tackles, 5 Assists |
| 16. | 10.00 | Week 07, 2020 | SF | @NE@NE | 3 Tackles, 3 Assists, 1.0 Sack |
| 16. | 10.00 | Week 11, 2019 | SF | AriAri | 8 Tackles, 2 Assists |
| 23. | 9.00 | Week 12, 2022 | SF | NONO | 4 Tackles, 1 Assist, 1 Fum Rcvy, 1 PD |
| 23. | 9.00 | Week 06, 2020 | SF | LARLAR | 9 Tackles |
| 25. | 8.00 | Week 15, 2024 | SF | LARLAR | 3 Tack, 5 Ass |
| 25. | 8.00 | Week 15, 2023 | SF | @Ari@Ari | 7 Tackles, 1 Assist |
| 25. | 8.00 | Week 12, 2023 | SF | @Sea@Sea | 5 Tackles, 3 Assists |
| 25. | 8.00 | Week 10, 2023 | SF | @Jac@Jac | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 08, 2023 | SF | CinCin | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 17, 2022 | SF | @LV@LV | 3 Tackles, 5 Assists |
| 25. | 8.00 | Week 02, 2022 | SF | SeaSea | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 08, 2020 | SF | @SEA@SEA | 7 Tackles, 1 Assist |
| 25. | 8.00 | Week 05, 2020 | SF | MIAMIA | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 14, 2019 | SF | @NO@NO | 6 Tackles, 1 Assist, 1 PD |
| 25. | 8.00 | Week 13, 2019 | SF | @Bal@Bal | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 12, 2019 | SF | GBGB | 6 Tackles, 2 Assists |
| 25. | 8.00 | Week 09, 2019 | SF | @Ari@Ari | 4 Tackles, 1.0 Sack |
| 38. | 7.00 | Week 13, 2023 | SF | @Phi@Phi | 2 Tackles, 5 Assists |
| 38. | 7.00 | Week 16, 2022 | SF | WasWas | 4 Tackles, 3 Assists |
| 38. | 7.00 | Week 10, 2022 | SF | LACLAC | 6 Tackles, 1 Assist |
| 38. | 7.00 | Week 16, 2020 | SF | @ARI@ARI | 6 Tackles, 1 Assist |
| 38. | 7.00 | Week 14, 2020 | SF | WASWAS | 6 Tackles, 1 Assist |
| 38. | 7.00 | Week 12, 2020 | SF | @LAR@LAR | 5 Tackles, 2 Assists |
| 38. | 7.00 | Week 09, 2020 | SF | GBGB | 4 Tackles, 3 Assists |
| 45. | 6.00 | Week 01, 2023 | SF | @Pit@Pit | 3 Tackles, 3 Assists |
| 45. | 6.00 | Week 06, 2022 | SF | @Atl@Atl | 4 Tackles, 2 Assists |
| 45. | 6.00 | Week 13, 2020 | SF | BUFBUF | 4 Tackles, 2 Assists |
| 45. | 6.00 | Week 01, 2020 | SF | AriAri | 3 Tackles, 2 Assists, 1 PD |
| 45. | 6.00 | Week 15, 2019 | SF | AtlAtl | 4 Tackles, 2 Assists |
| 50. | 5.00 | Week 03, 2023 | SF | NYGNYG | 4 Tackles, 1 Assist |