*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 13.00 | Week 04, 2024 | SF | NE NE | 2 Tack, 1 Ass, 2.50 Sack |
| 2. | 9.00 | Week 05, 2023 | SF | DalDal | 1 Tackle, 1 Assist, 1.0 Sack, 1 Fum Rcvy |
| 3. | 7.00 | Week 03, 2022 | SF | @Den@Den | 1 Tackle, 2 Assists, 1.0 Sack |
| 4. | 6.00 | Week 02, 2024 | SF | @Min@Min | 1 Tack, 1 Ass, 1.00 Sack |
| 4. | 6.00 | Week 11, 2022 | SF | @Ari@Ari | 2 Tackles, 1.0 Sack |
| 4. | 6.00 | Week 07, 2020 | SF | @NE@NE | 1 Tackle, 1 Assist, 1.0 Sack |
| 7. | 5.00 | Week 12, 2021 | SF | MINMIN | 1 Tackle, 1 Assist, 1 FF |
| 7. | 5.00 | Week 12, 2020 | SF | @LAR@LAR | 2 Tackles, 1 Fum Rcvy |
| 9. | 4.00 | Week 15, 2023 | SF | @Ari@Ari | 4 Tackles |
| 9. | 4.00 | Week 06, 2023 | SF | @Cle@Cle | 2 Tackles, 2 Assists |
| 9. | 4.00 | Week 04, 2022 | SF | LARLAR | 1 Tackle, 2 Assists, 1 PD |
| 9. | 4.00 | Week 02, 2022 | SF | SeaSea | 3 Tackles, 1 Assist |
| 9. | 4.00 | Week 13, 2020 | SF | BUFBUF | 3 Tackles, 1 PD |
| 14. | 3.00 | Week 18, 2023 | SF | LARLAR | 2 Tackles, 1 Assist |
| 14. | 3.00 | Week 16, 2023 | SF | BalBal | |
| 14. | 3.00 | Week 12, 2023 | SF | @Sea@Sea | 1 Assist, 0.5 Sack |
| 17. | 2.00 | Week 06, 2024 | SF | @Sea@Sea | 1 Tack, 1 Ass |
| 17. | 2.00 | Week 14, 2023 | SF | SeaSea | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 10, 2022 | SF | LACLAC | 2 Assists |
| 17. | 2.00 | Week 18, 2021 | SF | @LAR@LAR | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 17, 2021 | SF | HOUHOU | 2 Assists |
| 17. | 2.00 | Week 16, 2021 | SF | @TEN@TEN | 2 Assists |
| 17. | 2.00 | Week 09, 2021 | SF | ARIARI | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 15, 2020 | SF | @DAL@DAL | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 05, 2020 | SF | MIAMIA | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 02, 2020 | SF | @NYJ@NYJ | 2 Tackles |
| 27. | 1.00 | Week 13, 2024 | SF | @Buf@Buf | 1 Tack |
| 27. | 1.00 | Week 07, 2024 | SF | KC KC | 1 Ass |
| 27. | 1.00 | Week 05, 2024 | SF | AriAri | 1 Tack |
| 27. | 1.00 | Week 03, 2024 | SF | @LAR@LAR | 1 Ass |
| 27. | 1.00 | Week 17, 2023 | SF | @Was@Was | 1 Assist |
| 27. | 1.00 | Week 13, 2023 | SF | @Phi@Phi | 1 PD |
| 27. | 1.00 | Week 08, 2023 | SF | CinCin | 1 Assist |
| 27. | 1.00 | Week 07, 2023 | SF | @Min@Min | 1 Tackle |
| 27. | 1.00 | Week 04, 2023 | SF | AriAri | 1 Tackle |
| 27. | 1.00 | Week 13, 2022 | SF | MiaMia | 1 Tackle |
| 27. | 1.00 | Week 12, 2022 | SF | NONO | 1 Assist |
| 27. | 1.00 | Week 08, 2022 | SF | @LAR@LAR | 1 Assist |
| 27. | 1.00 | Week 07, 2022 | SF | KCKC | 1 Tackle |
| 27. | 1.00 | Week 06, 2022 | SF | @Atl@Atl | 1 Tackle |
| 27. | 1.00 | Week 05, 2022 | SF | @Car@Car | 1 Tackle |
| 27. | 1.00 | Week 15, 2021 | SF | ATLATL | 1 Assist |
| 27. | 1.00 | Week 14, 2021 | SF | @CIN@CIN | 1 Tackle |
| 27. | 1.00 | Week 11, 2021 | SF | @Jac@Jac | 1 Tackle |
| 27. | 1.00 | Week 10, 2021 | SF | LARLAR | 1 Tackle |
| 27. | 1.00 | Week 08, 2021 | SF | @CHI@CHI | 1 Tackle |
| 27. | 1.00 | Week 01, 2021 | SF | @DET@DET | 1 Assist |
| 27. | 1.00 | Week 09, 2020 | SF | GBGB | 1 Tackle |
| 27. | 1.00 | Week 08, 2020 | SF | @SEA@SEA | 1 Tackle |
| 27. | 1.00 | Week 04, 2020 | SF | PHIPHI | 1 Tackle |