*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 15.00 | Week 11, 2024 | NYJ | IndInd | 2 Tack, 3 Ass, 1.00 Sack, 1 FF, 1 Fum Rcvy |
| 2. | 12.00 | Week 13, 2023 | SF | @Phi@Phi | 2 Tackles, 2 Assists, 2.0 Sacks |
| 3. | 9.00 | Week 18, 2024 | NYJ | MiaMia | 2 Tack, 1.00 Sack, 1 FF |
| 3. | 9.00 | Week 10, 2020 | SF | @NO@NO | 1 Tackle, 2 Assists, 1.5 Sacks |
| 5. | 8.00 | Week 12, 2020 | SF | @LAR@LAR | 2 Assists, 1 Int, 1 PD |
| 6. | 6.00 | Week 15, 2024 | NYJ | @Jac@Jac | 2 Tack, 1.00 Sack |
| 6. | 6.00 | Week 07, 2024 | NYJ | @Pit@Pit | 5 Tack, 1 Ass |
| 6. | 6.00 | Week 15, 2023 | SF | @Ari@Ari | 1 Tackle, 1 Assist, 1.0 Sack |
| 6. | 6.00 | Week 03, 2021 | SF | GBGB | 2 Tackles, 4 Assists |
| 10. | 5.00 | Week 03, 2024 | NYJ | NE NE | 1 Tack, 1.00 Sack |
| 10. | 5.00 | Week 14, 2023 | SF | SeaSea | 2 Tackles, 1 Assist, 0.5 Sack |
| 10. | 5.00 | Week 04, 2020 | SF | PHIPHI | 2 Tackles, 2 Assists, 1 PD |
| 13. | 4.00 | Week 08, 2024 | NYJ | @NE @NE | 1 Tack, 1 Ass, 0.50 Sack |
| 13. | 4.00 | Week 14, 2020 | SF | WASWAS | 3 Tackles, 1 Assist |
| 15. | 3.00 | Week 16, 2024 | NYJ | LARLAR | 2 Tack, 1 Ass |
| 15. | 3.00 | Week 10, 2024 | NYJ | @Ari@Ari | 1 Tack, 2 Ass |
| 15. | 3.00 | Week 06, 2024 | NYJ | BufBuf | 2 Tack, 1 Ass |
| 15. | 3.00 | Week 05, 2024 | NYJ | @Min@Min | 1 Tack, 2 Ass |
| 15. | 3.00 | Week 02, 2024 | NYJ | @Ten@Ten | 3 Tack |
| 15. | 3.00 | Week 01, 2024 | NYJ | @SF @SF | 3 Tack |
| 15. | 3.00 | Week 06, 2023 | SF | @Cle@Cle | 2 Assists, 1 PD |
| 15. | 3.00 | Week 15, 2020 | SF | @DAL@DAL | 1 Tackle, 2 Assists |
| 15. | 3.00 | Week 13, 2020 | SF | BUFBUF | 1 Tackle, 2 Assists |
| 15. | 3.00 | Week 09, 2020 | SF | GBGB | 2 Tackles, 1 Assist |
| 15. | 3.00 | Week 05, 2020 | SF | MIAMIA | 2 Tackles, 1 Assist |
| 15. | 3.00 | Week 03, 2020 | SF | @NYG@NYG | 1 Tackle, 1 Assist, 1 PD |
| 27. | 2.00 | Week 09, 2024 | NYJ | HouHou | 1 Tack, 1 Ass |
| 27. | 2.00 | Week 18, 2023 | SF | LARLAR | 1 Tackle, 1 Assist |
| 27. | 2.00 | Week 17, 2023 | SF | @Was@Was | 2 Assists |
| 27. | 2.00 | Week 11, 2023 | SF | TBTB | 1 Tackle, 1 Assist |
| 27. | 2.00 | Week 10, 2023 | SF | @Jac@Jac | 1 Tackle, 1 PD |
| 27. | 2.00 | Week 02, 2023 | SF | @LAR@LAR | 1 Tackle, 1 PD |
| 27. | 2.00 | Week 07, 2020 | SF | @NE@NE | 1 Tackle, 1 Assist |
| 27. | 2.00 | Week 06, 2020 | SF | LARLAR | 1 Assist, 1 PD |
| 27. | 2.00 | Week 02, 2020 | SF | @NYJ@NYJ | 1 Tackle, 1 Assist |
| 36. | 1.00 | Week 17, 2024 | NYJ | @Buf@Buf | 1 Tack |
| 36. | 1.00 | Week 14, 2024 | NYJ | @Mia@Mia | 1 Tack |
| 36. | 1.00 | Week 04, 2024 | NYJ | DenDen | 1 Tack |
| 36. | 1.00 | Week 16, 2023 | SF | BalBal | |
| 36. | 1.00 | Week 12, 2023 | SF | @Sea@Sea | 1 Tackle |
| 36. | 1.00 | Week 08, 2023 | SF | CinCin | 1 Tackle |
| 36. | 1.00 | Week 07, 2023 | SF | @Min@Min | 1 Tackle |
| 36. | 1.00 | Week 04, 2023 | SF | AriAri | 1 Tackle |
| 36. | 1.00 | Week 01, 2023 | SF | @Pit@Pit | 1 Tackle |
| 36. | 1.00 | Week 18, 2022 | SF | AriAri | 1 Assist |
| 36. | 1.00 | Week 16, 2022 | SF | WasWas | 1 Assist |
| 36. | 1.00 | Week 03, 2022 | SF | @Den@Den | 1 Tackle |
| 36. | 1.00 | Week 02, 2022 | SF | SeaSea | 1 Tackle |
| 36. | 1.00 | Week 04, 2021 | SF | SEASEA | 1 Assist |
| 36. | 1.00 | Week 02, 2021 | SF | @PHI@PHI | 1 Assist |