*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 21.00 | Week 01, 2024 | Buf | AriAri | 6 Tack, 3.00 Sack, 1 FF |
| 2. | 15.00 | Week 05, 2021 | Buf | @KC@KC | 4 Tackles, 1 Assist, 1.0 Sack, 1 Int, 1 PD |
| 3. | 14.00 | Week 14, 2022 | Buf | NYJNYJ | 2 Tackles, 2.0 Sacks, 1 FF, 1 PD |
| 4. | 13.00 | Week 02, 2021 | Buf | @MIA@MIA | 3 Tackles, 2 Assists, 2.0 Sacks |
| 5. | 12.00 | Week 04, 2023 | Buf | MiaMia | 3 Tackles, 2.0 Sacks, 1 PD |
| 6. | 11.00 | Week 13, 2024 | Buf | SF SF | 4 Tack, 1.00 Sack, 1 Fum Rcvy |
| 6. | 11.00 | Week 10, 2024 | Buf | @Ind@Ind | 3 Tack, 1 Ass, 1.00 Sack, 1 FF |
| 6. | 11.00 | Week 09, 2024 | Buf | MiaMia | 4 Tack, 3 Ass, 1.00 Sack |
| 9. | 10.00 | Week 10, 2023 | Buf | DenDen | 4 Tackles, 2 Assists, 1.0 Sack |
| 9. | 10.00 | Week 17, 2021 | Buf | ATLATL | 3 Tackles, 1.0 Sack, 1 FF |
| 11. | 9.00 | Week 18, 2022 | Buf | NENE | 4 Tackles, 1 Assist, 1.0 Sack |
| 11. | 9.00 | Week 03, 2022 | Buf | @Mia@Mia | 2 Tackles, 1 Assist, 1.5 Sacks |
| 11. | 9.00 | Week 01, 2022 | Buf | @LAR@LAR | 4 Tackles, 1.0 Sack, 1 PD |
| 14. | 8.00 | Week 15, 2024 | Buf | @Det@Det | 3 Tack, 1 Ass, 1.00 Sack |
| 14. | 8.00 | Week 08, 2022 | Buf | GBGB | 3 Tackles, 1 Assist, 1.0 Sack |
| 14. | 8.00 | Week 02, 2022 | Buf | TenTen | 3 Tackles, 1 Assist, 1.0 Sack |
| 17. | 7.00 | Week 16, 2024 | Buf | NE NE | 2 Tack, 2 Ass, 1 FF |
| 17. | 7.00 | Week 07, 2024 | Buf | TenTen | 2 Tack, 3 Ass, 0.50 Sack |
| 17. | 7.00 | Week 12, 2023 | Buf | @Phi@Phi | 3 Tackles, 1 Assist, 1 Fum Rcvy |
| 17. | 7.00 | Week 11, 2021 | Buf | INDIND | 5 Tackles, 2 Assists |
| 21. | 6.00 | Week 17, 2024 | Buf | NYJNYJ | 1 Tack, 2 Ass, 0.50 Sack, 1 PD |
| 21. | 6.00 | Week 08, 2024 | Buf | @Sea@Sea | 3 Tack, 1 Ass, 2 PD |
| 21. | 6.00 | Week 16, 2023 | Buf | @LAC@LAC | |
| 21. | 6.00 | Week 03, 2023 | Buf | @Was@Was | 2 Tackles, 1.0 Sack |
| 21. | 6.00 | Week 04, 2022 | Buf | @Bal@Bal | 2 Tackles, 2 Assists, 0.5 Sack |
| 21. | 6.00 | Week 18, 2021 | Buf | NYJNYJ | 5 Tackles, 1 PD |
| 27. | 5.00 | Week 14, 2023 | Buf | @KC@KC | 2 Assists, 0.5 Sack, 1 PD |
| 27. | 5.00 | Week 13, 2022 | Buf | @NE@NE | 1 Tackle, 3 Assists, 1 PD |
| 29. | 4.00 | Week 02, 2024 | Buf | @Mia@Mia | 2 Tack, 2 Ass |
| 29. | 4.00 | Week 15, 2023 | Buf | DalDal | 1 Tackle, 1 Assist, 0.5 Sack |
| 29. | 4.00 | Week 06, 2023 | Buf | NYGNYG | 3 Tackles, 1 Assist |
| 29. | 4.00 | Week 02, 2023 | Buf | LVLV | 2 Tackles, 1 Assist, 1 PD |
| 29. | 4.00 | Week 01, 2023 | Buf | @NYJ@NYJ | 1 Tackle, 1 FF |
| 29. | 4.00 | Week 15, 2022 | Buf | MiaMia | 3 Tackles, 1 Assist |
| 29. | 4.00 | Week 13, 2021 | Buf | NENE | 4 Tackles |
| 29. | 4.00 | Week 03, 2021 | Buf | WASWAS | 3 Tackles, 1 Assist |
| 37. | 3.00 | Week 06, 2024 | Buf | @NYJ@NYJ | 2 Tack, 1 Ass |
| 37. | 3.00 | Week 08, 2023 | Buf | TBTB | 2 Tackles, 1 Assist |
| 37. | 3.00 | Week 12, 2021 | Buf | @NO@NO | 2 Tackles, 1 Assist |
| 37. | 3.00 | Week 10, 2021 | Buf | @NYJ@NYJ | 3 Tackles |
| 41. | 2.00 | Week 04, 2024 | Buf | @Bal@Bal | 2 Tack |
| 41. | 2.00 | Week 11, 2023 | Buf | NYJNYJ | 2 Tackles |
| 41. | 2.00 | Week 09, 2023 | Buf | @Cin@Cin | 1 Assist, 1 PD |
| 41. | 2.00 | Week 06, 2022 | Buf | @KC@KC | 1 Tackle, 1 PD |
| 41. | 2.00 | Week 15, 2021 | Buf | CARCAR | 1 Tackle, 1 PD |
| 41. | 2.00 | Week 08, 2021 | Buf | MIAMIA | 1 Tackle, 1 Assist |
| 41. | 2.00 | Week 06, 2021 | Buf | @TEN@TEN | 2 Tackles |
| 41. | 2.00 | Week 04, 2021 | Buf | HOUHOU | 2 Tackles |
| 41. | 2.00 | Week 01, 2021 | Buf | PITPIT | 2 Tackles |
| 50. | 1.00 | Week 14, 2024 | Buf | @LAR@LAR | 1 Ass |