*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 23.00 | Week 12, 2012 | SF | @NO@NO | 4 Tackles, 1 Assist, 1.5 Sacks, 1 Int, 1 TD, 1 PD |
| 2. | 22.00 | Week 14, 2009 | SF | AriAri | 4 Tackles, 3.0 Sacks, 2 FF |
| 3. | 18.00 | Week 11, 2013 | SF | @NO@NO | 2 Tackles, 1.0 Sack, 1 Int, 1 FF, 1 Fum Rcvy, 1 PD |
| 3. | 18.00 | Week 10, 2013 | SF | CarCar | 4 Tackles, 1 Assist, 3.0 Sacks, 1 PD |
| 5. | 16.00 | Week 12, 2013 | SF | @Was@Was | 6 Tackles, 1 Assist, 2.0 Sacks, 1 PD |
| 6. | 14.00 | Week 04, 2013 | SF | @StL@StL | 5 Tackles, 2 Assists, 1.5 Sacks, 1 PD |
| 6. | 14.00 | Week 08, 2011 | SF | CleCle | 3 Tackles, 2.0 Sacks, 1 FF |
| 6. | 14.00 | Week 17, 2010 | SF | AriAri | 3 Tackles, 1 Assist, 1.0 Sack, 1 Int, 1 PD |
| 9. | 13.00 | Week 07, 2015 | SF | SeaSea | 2 Tackles, 3 Assists, 2.0 Sacks |
| 9. | 13.00 | Week 06, 2014 | SF | @Stl@Stl | 5 Tackles, 2.0 Sacks |
| 9. | 13.00 | Week 02, 2013 | SF | @Sea@Sea | 7 Tackles, 2 Assists, 1.0 Sack |
| 9. | 13.00 | Week 01, 2007 | Cin | BalBal | 5 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 13. | 12.00 | Week 13, 2010 | SF | @GB@GB | 4 Tackles, 2.0 Sacks |
| 13. | 12.00 | Week 16, 2009 | SF | DetDet | 2 Tackles, 1.0 Sack, 2 FF |
| 15. | 11.00 | Week 03, 2012 | SF | @Min@Min | 5 Tackles, 3 Assists, 1 FF |
| 16. | 10.00 | Week 16, 2016 | SF | @LA@LA | 4 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 16. | 10.00 | Week 03, 2016 | SF | @Sea@Sea | 3 Tackles, 1 Assist, 1.0 Sack, 2 PD |
| 16. | 10.00 | Week 10, 2014 | SF | @NO@NO | 2 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 16. | 10.00 | Week 08, 2010 | SF | DenDen | 3 Tackles, 1.0 Sack, 1 FF |
| 20. | 9.00 | Week 16, 2015 | SF | @Det@Det | 1 Tackle, 2 Assists, 1.5 Sacks |
| 20. | 9.00 | Week 15, 2015 | SF | CinCin | 3 Tackles, 2 Assists, 1.0 Sack |
| 20. | 9.00 | Week 04, 2015 | SF | GBGB | 5 Tackles, 1.0 Sack |
| 20. | 9.00 | Week 13, 2014 | SF | SeaSea | 3 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 20. | 9.00 | Week 10, 2012 | SF | StLStL | 6 Tackles, 3 PD |
| 20. | 9.00 | Week 06, 2011 | SF | @Det@Det | 4 Tackles, 1 Assist, 1.0 Sack |
| 20. | 9.00 | Week 13, 2009 | SF | @Sea@Sea | 5 Tackles, 1.0 Sack |
| 27. | 8.00 | Week 14, 2015 | SF | @Cle@Cle | 4 Tackles, 1 Assist, 1 Fum Rcvy |
| 27. | 8.00 | Week 03, 2013 | SF | IndInd | 7 Tackles, 1 Assist |
| 27. | 8.00 | Week 09, 2011 | SF | @Was@Was | 2 Tackles, 2 Assists, 1.0 Sack |
| 27. | 8.00 | Week 03, 2011 | SF | @Cin@Cin | 1 Tackle, 3 Assists, 1.0 Sack |
| 31. | 7.00 | Week 15, 2016 | SF | @Atl@Atl | 4 Tackles, 1 FF |
| 31. | 7.00 | Week 07, 2016 | SF | TBTB | 3 Tackles, 2 Assists, 0.5 Sack |
| 31. | 7.00 | Week 01, 2016 | SF | LALA | 2 Tackles, 1 Assist, 1.0 Sack |
| 31. | 7.00 | Week 11, 2015 | SF | @Sea@Sea | 2 Tackles, 1 Assist, 1.0 Sack |
| 31. | 7.00 | Week 15, 2014 | SF | @Sea@Sea | 3 Tackles, 1.0 Sack |
| 31. | 7.00 | Week 12, 2014 | SF | WasWas | 3 Tackles, 1 Fum Rcvy, 1 PD |
| 31. | 7.00 | Week 17, 2012 | SF | AriAri | 3 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 03, 2017 | GB | CinCin | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 13, 2016 | SF | @Chi@Chi | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 12, 2016 | SF | @Mia@Mia | 1 Tackle, 3 Assists, 0.5 Sack |
| 38. | 6.00 | Week 11, 2016 | SF | NENE | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 14, 2013 | SF | SeaSea | 5 Tackles, 1 PD |
| 38. | 6.00 | Week 07, 2013 | SF | @Ten@Ten | 1 Tackle, 1.0 Sack, 1 PD |
| 38. | 6.00 | Week 08, 2012 | SF | @Ari@Ari | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 05, 2012 | SF | BufBuf | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 04, 2012 | SF | @NYJ@NYJ | 1 Tackle, 1 Assist, 1.0 Sack |
| 38. | 6.00 | Week 01, 2012 | SF | @GB@GB | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 17, 2011 | SF | @StL@StL | 2 Tackles, 1.0 Sack |
| 38. | 6.00 | Week 15, 2011 | SF | PitPit | 4 Tackles, 2 Assists |
| 38. | 6.00 | Week 11, 2011 | SF | AriAri | 2 Tackles, 1.0 Sack |