| Week | Add | Drop |
| Pre-Season |
Round 1: RP Kevin Ginkel - Ari Round 2: OF Adam Duvall - Atl Round A: 3B Coby Mayo - Bal Round B: C Ethan Salas - SD |
Round A: C Yasmani Grandal - Pit Round B: 1B Joshua Bell - Ari |
| Week 1 |
Round 2: C Travis d'Arnaud - Atl | |
| Week 2 |
Round 1: OF Heston Kjerstad - Bal Round 2: 2B Brendan Donovan - StL | |
| Week 3 |
Round 2: C Ivan Herrera - StL |
Round 2: C Travis d'Arnaud - Atl |
| Week 4 |
Round 1: RP James McArthur - KC | |
| Week 5 |
Round 1: OF Hunter Goodman - Col Round 2: OF Jo Adell - LAA |
Round 1: RP Will Smith - KC Round 2: 3B Anthony Rendon - LAA |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: SP Zack Littell - TB |
Round 1: OF Adam Duvall - Atl Round 2: RP Yuki Matsui - SD Round 2: RP Griffin Jax - Min |
| Week 7 |
Round 1: RP Michael Kopech - LAD Round 2: SP Cade Horton - ChN |
Round 2: RP Kevin Ginkel - Ari |
| Week 8 |
Round 1: OF Luis Matos - SF Round 2: 2B Connor Norby - Mia |
Round 1: OF Hunter Goodman - Col Round 2: SP Zack Littell - TB |
| Week 9 |
Round 1: OF Kerry Carpenter - Det Round 1: OF Kerry Carpenter - Det |
Round 1: OF Jack Suwinski - Pit Round 1: OF Jack Suwinski - Pit |
| Week 10 |
Round 1: 2B Miguel Vargas - ChA Round 2: SP Matt Waldron - SD |
Round 1: C Ivan Herrera - StL |
| Week 11 |
Round 1: SP Hunter Brown - Hou Round 2: SS Adael Amador - Col | |
| Week 12 |
Round 1: 3B Justyn-Henry Malloy - Det Round 1: OF Justyn-Henry Malloy - Det Round 2: 2B Enmanuel Valdez - Bos |
Round 1: OF Luis Matos - SF Round 2: SP Casey Mize - Det |
| Week 13 |
Round 1: 1B Ben Rice - NYA Round 2: SP David Peterson - NYN |
Round 1: SP Cade Horton - ChN |
| Week 14 |
Round 1: 1B Jhonkensy Noel - Cle Round 2: RP Hector Neris - ChN |
Round 2: 3B Patrick Wisdom - ChN |
| Week 15 |
Round 1: SP Jose Quintana - NYN Round 2: 1B Moises Ballesteros - ChN |
Round 1: 2B Enmanuel Valdez - Bos |
| Week 16 |
Round 1: OF Parker Meadows - Det |
Round 1: 2B Davis Schneider - Tor |
| Week 18 |
Round 1: SP Jackson Jobe - Det Round 2: SP Ryne Nelson - Ari |
Round 2: SP Logan Allen - Cle |
| Week 19 |
Round 1: SP Trevor Rogers - Bal |
Round 1: 3B Tyler Black - Mil |
| Week 20 |
Round 1: 2B Christian Moore - LAA |
Round 1: RP James McArthur - KC |
| Week 22 |
Round 2: 1B Nick Kurtz - Oak |
Round 2: SP Trevor Rogers - Bal |
| 1st Team | 2nd Team |
| Pre-Season | |
| Erie SeaWolves | The Shogun of Harlem |
|
1B
Josh Naylor
Cle |
|
| Pre-Season | |
| Erie SeaWolves | Cedar Rapids Kernels |
|
3B
Nolan Arenado
StL |
|
| Pre-Season | |
| Erie SeaWolves | Mama's Boys |
|
SS
Corey Seager
Tex |
SS
Junior Caminero
TB OF Wyatt Langford Tex |
| Pre-Season | |
| Erie SeaWolves | Cedar Rapids Kernels |
|
SP
Logan Webb
SF |
|
| Week 4 | |
| Erie SeaWolves | Palm Beach Cardinals |
|
SP
Dylan Cease
SD SP Logan Webb SF OF Riley Greene Det |
1B
Freddie Freeman
LAD SP Casey Mize Det SP Bailey Ober Min |
| Week 10 | |
| Erie SeaWolves | Cedar Rapids Kernels |
|
SP
Cole Ragans
KC OF Adolis Garcia Tex |
SP
Ryan Pepiot
TB 2B Matt McLain Cin |
| Week 11 | |
| Erie SeaWolves | The Shogun of Harlem |
|
2B
Gleyber Torres
NYA OF Bryan Reynolds Pit SP Bailey Ober Min |
OF
Owen Caissie
ChN SP Reese Olson Det |
| Week 13 | |
| Erie SeaWolves | The Shogun of Harlem |
|
SP
Yu Darvish
SD |
OF
Masataka Yoshida
Bos |
| Week 14 | |
| Erie SeaWolves | The Shogun of Harlem |
|
SP
Reese Olson
Det SP Matt Waldron SD |
SS
Brooks Lee
Min |
| Week 14 | |
| Erie SeaWolves | Dave's Destroyers III |
|
SP
Hunter Brown
Hou |
OF
Lars Nootbaar
StL |
| Week 15 | |
| Erie SeaWolves | The Plantation |
|
1B
Josh Naylor
Cle Round 15, 3rd Pick (C Patrick Bailey SF) |
OF
Eloy Jimenez
ChA Round 1, 10th Pick (OF Evan Carter Tex) Round 6, 10th Pick (2B Travis Bazzana Cle) |
| Week 17 | |
| Erie SeaWolves | Buffalo Yankees |
|
OF
Lars Nootbaar
StL SS Ezequiel Tovar Col Round 18, 3rd Pick (1B Joshua Bell Was) Round 19, 3rd Pick (OF Jo Adell LAA) |
SP
Spencer Strider
Atl Round 4, 12th Pick (SP Jared Jones Pit) |